Effect of Some natural products against Ehrlich Ascites Carcinoma in mice: A Review

Authors

  • Haneen Mushtaq Hameed Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq
  • Ahmed Flayyih Hasan Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq
  • Zainab Haytham Razooki Department of Plant Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq

DOI:

https://doi.org/10.59746/jfms.v1i1.84

Keywords:

natural products, Ehrlich ascites carcinoma, DNA damage, Ehrlich model

Abstract

Cancer is a serious disease and it is one of the main causes of death, and it is considered the second cause, after people who suffer from heart failure. Through the statistics, Breast cancer is one of the most common types of cancer, with a rate of 99% in women and 1% in men. It is very complex, and patients with this type of cancer may face numerous challenges during their treatment period. It was determined that the death rate from cancer had decreased by 1.5%, but it is expected to increase in the future due to an increase in cancer cases (breast, prostate). Ehrlich model is a cancer that grows inside a mouse. Its origin is spontaneous mammary carcinoma, and when it spreads within the mouse, it takes two forms, either ascitic or solid. Ehrlich's ascites carcinoma is a spontaneous breast cancer that has a very high importance in scientific research. It is undifferentiated and has a short life. This type of cancer was used for the first time in 1932, when it was used inside the mouse in the abdomen, and a type of fluid was obtained for this called ( Ehrlich's ascites) due to the liquid substance on which cancer cells depend and consider it food and a means for rapid tumor growth, EAC deficiency causes anemia and thus causes a decrease in red blood cells or hemoglobin, EAC causes an increase in urea and a decrease in creatinine, and EAC causes an increase in liver enzymes and a decrease in total protein.Natural products are the only and most effective products that lead to the development of drugs, especially anti-cancer drugs and anti-inflammatories. Through studies, it has become clear that natural products are a source of drugs.

References

• Abd Elrazik, N. A., El-Mesery, M., El-Karef, A., Eissa, L. A., & El Gayar, A. M. (2022). Sesamol upregulates death receptors and acts as a chemosensitizer in solid ehrlich carcinoma model in mice. Nutrition and Cancer, 74(1), 250-264. https://doi.org/10.1080/01635581.2020.1871496

• Abdel-Maksoud, H., Elsenosy, Y. A., El-Far, A. H., & Randa, M. K. (2014). Biochemical effect of costus speciosus on Ehrlich ascites carcinoma (EAC) in female albino mice. Benha Vet Med J, 26, 200-21. https://doi.org/10.1080/01635581.2020.1871496

• Adriana, M., Suciu, S., Clichici, S., Daicoviciu, D., Pop, N., & Potescu, I. D. (2006). Study on the effects of grape seed extract in ehrlich ascitic carcinoma. Bulletin of the University of Agricultural Sciences and Veterinary Medicine, 63(1-2), 114-19.‏‏‏‏

• Ahmed, H. H., Hegazi, M. M., Abd-Allac, H. I., Eskander, E. F., & Ellithey, M. S. (2011). Antitumour and antioxidant activity of some Red Sea seaweeds in Ehrlich ascites carcinoma in vivo. Zeitschrift für Naturforschung C, 66(7-8), 367-376. https://doi.org/10.1515/znc-2011-7-808

• Ali, H. A., Hussein, M. A., & Mohammed, W. E. (2014). Comparative effects of purslane seed oil (PSO) and 5-Flourourasil on ehrlich ascites carcinoma (EAC) in female albino mice. Int J Pharma Sci, 4, 424-30. https://doi.org/10.2174/1567201811666140515101130

• Alimirzaie, S., Bagherzadeh, M., & Akbari, M. R. (2019). Liquid biopsy in breast cancer: A comprehensive review. Clinical genetics, 95(6), 643-660. https://doi.org/10.1111/cge.13514

• Awad, B. M., Abd-Alhaseeb, M. M., Habib, E. S., Ibrahim, A. K., & Ahmed, S. A. (2019). Antitumor activity of methoxylated flavonoids separated from Achillea fragrantissima extract in Ehrlich’s ascites carcinoma model in mice. Journal of Herbmed Pharmacology, 9(1), 28-34.

• Atta, F. A., Tousson, E., A Dabour, N., A Massoud, A., & F Hasan, A. (2019). Amitriptyline induced alterations in liver and kidney functions and structures in male rats. Asian Journal of Research in Medical and Pharmaceutical Sciences, 7(4), 1-10.‏ https://doi.org/10.9734/ajrimps/2019/v7i430128

• Al-Dulimia, A. G., Hasan, A. F., & Al–Mogadamy, O. A. (2022). Anti-tumor Activity of Gold nanoparticles by Use High Content Screening Technique (HCS). Journal of Medical and Life Science, 4(3), 27-40.‏ https://doi.org/10.21608/jmals.2022.256487

• Alankooshi, A. A., Hasan, A. F., Tousson, E., El-Atrsh, A., & Mohamed, T. M. (2023). Impact of coriander seeds extract against thyroidectomy induced testicular damage and DNA replication in male rats. OnLine J Biol Sci, 23(2), 193-201.‏ https://doi.org/10.3844/ojbsci.2023.193.201

• Abbood, A. S., Lazm, A. M., & Hasan, A. F. (2023). Study of histopathological changes and the levels of TNF-α in Preterm Preeclamptic women. Journal of AL-Farabi for Medical Sciences, 1(1), 10-10.‏ https://doi.org/10.59746/jfms.v1i1.19

• Britt, K. L., Cuzick, J., & Phillips, K. A. (2020). Key steps for effective breast cancer prevention. Nature Reviews Cancer, 20(8), 417-436. https://doi.org/10.1038/s41568-020-0266-x

• Clark, A. M. (1996). Natural products as a resource for new drugs. Pharmaceutical research, 13, 1133-1141. https://doi.org/10.1023/a:1016091631721

• Dashora, N., Sodde, V., Bhagat, J., S Prabhu, K., & Lobo, R. (2011). Antitumor activity of Dendrophthoe falcata against ehrlich ascites carcinoma in swiss albino mice. Pharmaceutical Crops, 2(1). https://doi.org/10.2174/2210290601102010001

• Demain, A. L., & Vaishnav, P. (2011). Natural products for cancer chemotherapy. Microbial biotechnology, 4(6), 687-699. https://doi.org/10.1111/j.1751-7915.2010.00221.x

• Dumas, A., Luis, I. V., Bovagnet, T., El Mouhebb, M., Di Meglio, A., Pinto, S., ... & Menvielle, G. (2020). Impact of breast cancer treatment on employment: results of a multicenter prospective cohort study (CANTO). Journal of Clinical Oncology, 38(7), 734. https://doi.org/10.1200/jco.19.01726

• El Sayed, R. A. A., Hanafy, Z. E. M., Abd El Fattah, H. F., & Mohamed, A. K. (2020). Possible antioxidant and anticancer effects of plant extracts from Anastatica hierochuntica, Lepidium sativum and Carica papaya against Ehrlich ascites carcinoma cells. Cancer Biol, 10(1), 1-16. https://doi.org/10.30574/ijsra.2023.10.1.0765

• El-khayat, Z., AbasOA, M. D., Elghreeb, M., Farrag, A. R., & Mostafa, N. (2016). Biochemical studies on the effect of flaxseed and corn oils on cell membrane phospholipids in Ehrlich ascites carcinoma and solid tumor in mice. Der Pharmacia Lettre, 8(9), 90-101.

• Ezz, A. M., Zaki, S., & Tabl, G. A. (2023). Anti-diabetic effects of pomegranate peel extract and L-carnitine on streptozotocin induced diabetes in rats. Biomedical and Pharmacology Journal, 16(3), 1827-1835.‏ https://doi.org/10.13005/bpj/2762

• Freeman, K., Geppert, J., Stinton, C., Todkill, D., Johnson, S., Clarke, A., & Taylor-Phillips, S. (2021). Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy. bmj, 374. https://doi.org/10.1136/bmj.n1872

• Gowda, N. G. S., Shiragannavar, V. D., Prabhuswamimath, S. C., Tuladhar, S., Chidambaram, S. B., & Santhekadur, P. K. (2022). Ehrlich Ascites carcinoma mice model for studying liver inflammation and fibrosis. Advances in Cancer Biology-Metastasis, 4, 100029. https://doi.org/10.1016/j.adcanc.2022.100029

• Gupta, M., Mazumder, U. K., Kumar, R. S., & Kumar, T. S. (2004). Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice. Acta Pharmacologica Sinica, 25, 1070-1076. https://doi.org/10.1254/jphs.94.177

• Gupta, M., Mazumder, U. K., Kumar, R. S., Sivakumar, T., & Vamsi, M. L. M. (2004). Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. Journal of Pharmacological Sciences, 94(2), 177-184.

• Harvey, A. L. (2008). Natural products in drug discovery. Drug discovery today, 13(19-20), 894-901. https://doi.org/10.1016/j.drudis.2008.07.004

• Hasan, A. F., Alankooshi, A. A., Abbood, A. S., Dulimi, A. G., Mohammed Al-Khuzaay, H., Elsaedy, E. A. & Tousson, E. (2023). Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice. OnLine Journal of Biological Sciences, 23(1), 103-108. https://doi.org/10.3844/ojbsci.2023.103.108.

• Hassan, A. I., & Abdel-Gawad, E. I. (2010). Effect of Zizyphus leaves extract on mice suffering from ehrlich ascites carcinoma. Nat. Sci, 8(11), 234-244.

• Hassan, A., Mohammed, L., Abd ElMoneim, M., & Abd ElBaky, A. (2019). Hepatic and renal protective effects of Annona muricata leaf and fruit extracts on Ehrlich ascites carcinoma in mice. Zagazig Veterinary Journal, 47(3), 234-247. https://doi.org/10.21608/zvjz.2019.12593.1040

• Hussien, A. M. A., Hussein, M. A., Mohammed, R. R., & Zayed, H. T. (2015). Cranberry Extract Enhance antioxidant Potential in Ehrlich’s Ascites Carcinoma–Bearing Female Albino Mice. World Journal of Pharmaceutical Sciences, 484-491. https://doi.org/10.1080/13880200802435788

• Hasan, A. F., Hameed, H. M., Tousson, E., Massoud, A., Atta, F., & Youssef, H. (2022). Role of Oral Supplementation of Damiana (Turnera diffusa) Reduces the Renal Toxicity, Apoptosis and DNA Damage Associated with Amitriptyline Administration in Rats. Biomedical and Pharmacology Journal, 15(3), 1245-1253.‏ https://doi.org/10.13005/bpj/2460

• ‏Islam, A., Selvan, T., Mazumder, U. K., Gupta, M., & Ghosal, S. (2008). Antitumour effect of phyllanthin and hypophyllanthin from Phyllanthus amarus against Ehrlich ascites carcinoma in mice. Pharmacologyonline, 2(2), 796-807.

• Kandar, C. C., Haldar, P. K., Gupta, M., & Mazumder, U. K. (2012). Effect of methanol extracts of Glinus oppositifolius and Trianthema decandra in mouse against ehrlich ascites carcinoma cell line in vivo. J Pharma Sci Tech, 2, 26-30.

• Kiran, V. U., Nagulu, M., Srinivas, M., Allenki, V., Mahendar, P., Reddy, Y. N., & Devarakonda, R. K. (2011). Antitumor activity of flavonoids against Ehrlich ascites carcinoma-induced mice. International Journal of Biomedical and Pharmaceutical Sciences, 5(1), 36-39. https://doi.org/10.2174/2210290601102010001

• Mallapur, S., Biradar, P. R., Kavatagimath, S. A., Patil, P., Patil, V., & Kudatarkar, N. (2021). Pharmacological Evaluation of Caesalpinia pulcherrima Leaf Extract for Anticancer Activity against Ehrlich Ascites Carcinoma Bearing Mice. Indian Journal of Pharmaceutical Education and Research, 55(1), 164-173. https://doi.org/10.5530/ijper.55.1.18

• Mansour, M. A., Ibrahim, W. M., Salama, M. M., & Salama, A. F. (2020). Dual inhibition of glycolysis and autophagy as a therapeutic strategy in the treatment of Ehrlich ascites carcinoma. Journal of Biochemical and Molecular Toxicology, 34(7), e22498. https://doi.org/10.1002/jbt.22498

• Mitra, S., & Dash, R. (2018). Natural products for the management and prevention of breast cancer. Evidence-based complementary and alternative medicine, 2018. https://doi.org/10.1155/2018/8324696

• Munira, S., Sultana, F., Mollika, S., Nesa, L., Ria, J., & Islam, M. M. (2013). Anti-neoplastic activities of Polygonum hydropiper Linn. against Ehrlich ascites carcinoma in Swiss Albino mice. Adv Biol Res, 7(1), 9-14.

• Mutar, T. F., Tousson, E., Hafez, E., Abo Gazia, M., & Salem, S. B. (2020). Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice. Environmental Toxicology, 35(4), 528-537.‏ https://doi.org/10.1002/tox.22888

• Nelson, D. R., Brown, J., Morikawa, A., & Method, M. (2022). Breast cancer-specific mortality in early breast cancer as defined by high-risk clinical and pathologic characteristics. Plos one, 17(2), e0264637. https://doi.org/10.1371/journal.pone.0264637

• Ozaslan, M., Karagoz, I. D., Kilic, I. H., & Guldur, M. E. (2011). Ehrlich ascites carcinoma. African journal of Biotechnology, 10(13), 2375-2378. https://doi.org/10.1016/j.pharep.2013.06.006

• Pasha, N., & Turner, N. C. (2021). Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatment. Nature cancer, 2(7), 680-692. https://doi.org/10.1038/s43018-021-00229-1

• Perveen, R., Islam, F., Khanum, J., & Yeasmin, T. (2012). Preventive effect of ethanol extract of Alpinia calcarata Rosc on Ehrlich's ascitic carcinoma cell induced malignant ascites in mice. Asian Pacific journal of tropical medicine, 5(2), 121-125. https://doi.org/10.1016/s1995-7645(12)60009-1

• Qureshi, S., Al-Harbi, M. M., Ahmed, M. M., Raza, M., Giangreco, A. B., & Shah, A. H. (1993). Evaluation of the genotoxic, cytotoxic, and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice. Cancer chemotherapy and pharmacology, 33, 130-138. https://doi.org/10.1007/bf00685330

• Reddy, L. A. L. I. N. I., Odhav, B., & Bhoola, K. D. (2003). Natural products for cancer prevention: a global perspective. Pharmacology & therapeutics, 99(1), 1-13. https://doi.org/10.1016/s0163-7258(03)00042-1

• Rouhi, A. M. (2003). Rediscovering natural products. Chemical & engineering news, 81(41), 77-77. https://doi.org/10.1021/cen-v081n041.p077

• Salem, F. S., Badr, M. O., & Neamat-Allah, A. N. (2011). Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital, 47(1), 89-95.‏‏ https://doi.org/10.1007/s42452-023-05493-7

• Sannigrahi, S., Mazumder, U. K., Pal, D., & Mishra, S. L. (2012). Terpenoids of methanol extract of Clerodendrum infortunatum exhibit anticancer activity against Ehrlich’s ascites carcinoma (EAC) in mice. Pharmaceutical biology, 50(3), 304-309. https://doi.org/10.3109/13880209.2011.604089

• Sarker, S. D., Latif, Z., & Gray, A. I. (2006). An introduction to natural products isolation. Natural products isolation, 1-25. https://doi.org/10.1385/1-59259-955-9:1

• Senthilkumar, R., Manivannan, R., Balasubramaniam, A., Sivakumar, T., & Rajkapoor, B. (2008). Effects of ethanol extract of Pisonia aculeata Linn. on ehrlich ascites carcinoma tumor bearing mice. International Journal of Green Pharmacy (IJGP), 2(1). https://doi.org/10.4103/0973-8258.39166

• Sheeja, K., & Kuttan, G. (2007). Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice. Integrative cancer therapies, 6(1), 66-73. https://doi.org/10.1177/1534735406298975

• Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. Ca Cancer J Clin, 73(1), 17-48.‏ https://doi.org/10.3322/caac.21763

• Singh, J., Singha, T., Naskar, A., Kundu, M., Harwansh, R. K., Mondal, A., ... & Maity, T. K. (2011). Synthesis and anti-proliferative activity of some isoindoline-1, 3-dione derivatives against ehrlich’s ascites carcinoma bearing mice model. Pharmacologyonline, 2(12), 976-987.

• Spei, M. E., Samoli, E., Bravi, F., La Vecchia, C., Bamia, C., & Benetou, V. (2019). Physical activity in breast cancer survivors: a systematic review and meta-analysis on overall and breast cancer survival. The Breast, 44, 144-152.‏‏‏‏ https://doi.org/10.1016/j.breast.2019.02.001

• Waks, A. G., & Winer, E. P. (2019). Breast cancer treatment: a review. Jama, 321(3), 288-300. https://doi.org/10.1001/jama.2018.19323

• Wang, Z. X., Li, Y. L., Pu, J. L., & Zhang, B. R. (2023). DNA damage-mediated neurotoxicity in Parkinson’s disease. International Journal of Molecular Sciences, 24(7), 6313.‏ https://doi.org/10.3390/ijms24076313

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Published

2024-02-29

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Vol. 1 No. 1 (2024): Journal of Al-Farabi for Medical Sciences

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